Healing Families

Publications

  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010 and older

Supporting Publications

Publications

Electrical functional Connectome (ELECTOME) network observed in the brain of a 'depressed' mouse.


Brain activity was recorded from many mice subjected to chronic social stress and non-stressed
controls. We used machine learning to map electrical activity in the brain that was related to depression. Brain areas and oscillatory frequency bands ranging from 1 to 50Hz areshown around the rim of the circle plot. Spectral power measures that contribute to the network are depicted by the highlights around the rim, and synchrony measures are depicted by the lines linking the brain regions. The depression Network activation in for the three part 'stress test' shown in the upper left. The Electome Score quantifies the strength of the depression network. The depressed mice are shown in red. The resilient mice are shown in green, and the non-stress mice are shown in black.

Links

Our Supporting Publications

R. Hultman, K. Ulrich, B. D. Sachs, C. Blount, D. E. Carlson, N. Ndubuizu, R. C. Bagot, E. Parise, M. T. Vu, N. M. Gallagher, J. Wang, A. J. Silva, K. Deisseroth, S. Mague, M. G. Caron, E. J. Nestler, L. Carin*, K. Dzirasa*. “Brain-wide electrical spatiotemporal dynamics encode depression vulnerability.” Cell. 2018 May 22;1-15. DOI: https://doi.org/10.1016/j.cell.2018.02.012

R. Hultman, S. Mague, Q. Li, B. Katz, N. Michel, L. Lin, J. Wang, L. David, C. Blount, R. Chandy, D. Carlson, K. Ulrich, L. Carin, D. Dunson, S. Kumar, K. Deisseroth, S. D. Moore, K. Dzirasa*. “Dysregulation of prefrontal cortex-mediated slow evolving limbic dynamics drives stress-induced emotional pathology.” Neuron, 2016 Jul 20;91(2):439-52. doi: 10.1016/j.neuron.2016.05.038

  1. S. Kumar, R. Hultman, D. N. Hughes, N. Michel, B. M. Katz, K. Dzirasa*. “Prefrontal cortex reactivity underlies trait vulnerability to chronic subordination stress.” Nature Communications, 2014, 5:4537 doi: 10.1038/ncomms5537.

Additional Publications

K. Dzirasa, S. Kumar, B.D. Sachs, M.G. Caron, M.A.L. Nicolelis."Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency." J Neurosci. 2013 Mar 6;33(10):4505-13

S. Kumar, S.J. Black, R, Hultman, S.T. Szabo, K.D. DeMaio, J. Du, B.M. Katz, G. Feng, H.E. Covington 3rd, K. Dzirasa. "Cortical Control of Affective Networks." J Neurosci. 2013 Jan 16;33(3):1116-29.
K. Dzirasa, S.H. Lisanby. "How does deep brain stimulation work?" Biol Psychiatry. 2012 Dec 1;72(11):892-4.

K. Dzirasa, H.E. Covington 3rd. "Increasing the validity of experimental models for depression." Ann N Y Acad Sci. 2012 Aug;1265:36-45.


K. Dzirasa, R. Fuentes, S. Kumar, J. M. Potes, M. A. L. Nicolelis. “Chronic in vivo multi-circuit neurophysiological recordings in mice.” Journal of Neuroscience Methods, 2011. 195(1): p. 36-46. 


K. Dzirasa, D. L. McGarity, A. Bhattacharya, D. Dunson, C. A. McClung, M. A. L. Nicolelis. “Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania.” Journal of Neuroscience, 2011. 31(17):6449-6456 

K. Dzirasa, L. Coque, M. M. Sidor, E. A. Dancy, J. S. Takahashi, C. A. McClung, M. A. L. Nicolelis. “Lithium ameliorates nucleus accumbens phase timing dysfunction in mouse model of mania.” Journal of Neuroscience, 2010. 30(48): p. 16314-16323

K. Dzirasa, H. W. Phillips, T. D. Sotnikova, A. Salahpour, S. Kumar, R. R. Gainetdinov, M. G. Caron, M. A. L. Nicolelis. “Noradrenergic control of corticostriato-thalamic and mesolimbic cross-structural synchrony.” Journal of Neuroscience, 2010 30(18): p. 6387-6397 


K. Dzirasa, A. J. Ramsey, D. Y. Takahashi, J. Stapleton, J. M. Potes, J. K. Williams, R. R. Gainetdinov, K. Sameshima, Marc G. Caron, Miguel A. L. Nicolelis. “Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling.” Journal of Neuroscience, 2009. 29(25): p. 8215-8224. 


K. Dzirasa, L. M. Santos, S. Ribeiro, J. Stapleton, R. R. Gainetdinov, M. G. Caron, M. A. L. Nicolelis. “Persistent hyperdopaminergia decreases hippocampal theta oscillation frequencies during quiet waking and REM sleep” PLoS ONE, 2009. 4(4): e5238