LPNE

Green and red waves represent two networks in the reward circuit. In healthy mice, the amplitude of the red network increases in parallel to the phase of the green network (red arrows). This timing does not happen correctly in the Clock mutants.

K. Dzirasa, L. Coque, M. M. Sidor, E. A. Dancy, J. S. Takahashi, C. A. McClung, M. A. L. Nicolelis. “Lithium ameliorates nucleus accumbens phase timing dysfunction in mouse model of mania.” Journal of Neuroscience, 2010. 30(48): p. 16314-16323

K. Dzirasa, D. L. McGarity, A. Bhattacharya, D. Dunson, C. A. McClung, M. A. L. Nicolelis. “Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania.” Journal of Neuroscience, 2011. 31(17):6449-6456 

R. Hultman, S. Mague, Q. Li, B. Katz, N. Michel, L. Lin, J. Wang, L. David, C. Blount, R. Chandy, D. Carlson, K. Ulrich, L. Carin, D. Dunson, S. Kumar, K. Deisseroth, S. D. Moore, K. Dzirasa*. “Dysregulation of prefrontal cortex-mediated slow evolving limbic dynamics drives stress-induced emotional pathology.” Neuron, 2016 Jul 20;91(2):439-52. doi: 10.1016/j.neuron.2016.05.038

1. S. Kumar, R. Hultman, D. N. Hughes, N. Michel, B. M. Katz, K. Dzirasa*. “Prefrontal cortex reactivity underlies trait vulnerability to chronic subordination stress.” Nature Communications, 2014, 5:4537 doi: 10.1038/ncomms5537.

K. Dzirasa, S. Kumar, B.D. Sachs, M.G. Caron, M.A.L. Nicolelis."Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency." J Neurosci. 2013 Mar 6;33(10):4505-13

K. Dzirasa, H.E. Covington 3rd. "Increasing the validity of experimental models for depression." Ann N Y Acad Sci. 2012 Aug;1265:36-45.

K. Dzirasa, R. Fuentes, S. Kumar, J. M. Potes, M. A. L. Nicolelis. “Chronic in vivo multi-circuit neurophysiological recordings in mice.” Journal of Neuroscience Methods, 2011. 195(1): p. 36-46. 

K. Dzirasa, H. W. Phillips, T. D. Sotnikova, A. Salahpour, S. Kumar, R. R. Gainetdinov, M. G. Caron, M. A. L. Nicolelis. “Noradrenergic control of corticostriato-thalamic and mesolimbic cross-structural synchrony.” Journal of Neuroscience, 2010 30(18): p. 6387-6397 

K. Dzirasa, A. J. Ramsey, D. Y. Takahashi, J. Stapleton, J. M. Potes, J. K. Williams, R. R. Gainetdinov, K. Sameshima, Marc G. Caron, Miguel A. L. Nicolelis. “Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling.” Journal of Neuroscience, 2009. 29(25): p. 8215-8224. 

K. Dzirasa, L. M. Santos, S. Ribeiro, J. Stapleton, R. R. Gainetdinov, M. G. Caron, M. A. L. Nicolelis. “Persistent hyperdopaminergia decreases hippocampal theta oscillation frequencies during quiet waking and REM sleep” PLoS ONE, 2009. 4(4): e5238