Electrical functional Connectome (ELECTOME) network observed in the brain of a 'depressed' mouse.
Brain activity was recorded from many mice subjected to chronic social stress and non-stressed
controls. We used machine learning to map electrical activity in the brain that was related to depression. Brain areas and oscillatory frequency bands ranging from 1 to 50Hz areshown around the rim of the circle plot. Spectral power measures that contribute to the network are depicted by the highlights around the rim, and synchrony measures are depicted by the lines linking the brain regions. The depression Network activation in for the three part 'stress test' shown in the upper left. The Electome Score quantifies the strength of the depression network. The depressed mice are shown in red. The resilient mice are shown in green, and the non-stress mice are shown in black.
Our Supporting Publications
R. Hultman, K. Ulrich, B. D. Sachs, C. Blount, D. E. Carlson, N. Ndubuizu, R. C. Bagot, E. Parise, M. T. Vu, N. M. Gallagher, J. Wang, A. J. Silva, K. Deisseroth, S. Mague, M. G. Caron, E. J. Nestler, L. Carin*, K. Dzirasa*. “Brain-wide electrical spatiotemporal dynamics encode depression vulnerability.” Cell. 2018 May 22;1-15. DOI: https://doi.org/10.1016/j.cell.2018.02.012
R. Hultman, S. Mague, Q. Li, B. Katz, N. Michel, L. Lin, J. Wang, L. David, C. Blount, R. Chandy, D. Carlson, K. Ulrich, L. Carin, D. Dunson, S. Kumar, K. Deisseroth, S. D. Moore, K. Dzirasa*. “Dysregulation of prefrontal cortex-mediated slow evolving limbic dynamics drives stress-induced emotional pathology.” Neuron, 2016 Jul 20;91(2):439-52. doi: 10.1016/j.neuron.2016.05.038