Green and red waves represent two networks in the reward circuit. In healthy mice, the amplitude of the red network increases in parallel to the phase of the green network (red arrows). This timing does not happen correctly in the Clock mutants.
- Mice with mutations in the circadian gene CLOCK (Clock mutants) exhibit behaviors similar to mania in humans
- Brain networks that control fear and reward processing having dysfunction timing the clock mutant mice.
- Treatment with lithium (a medication used to treat bipolar disorder in humans) repairs normal timing in the reward network of Clock mice, and makes them behave normally
Our Supporting Publications
R. Hultman, S. Mague, Q. Li, B. Katz, N. Michel, L. Lin, J. Wang, L. David, C. Blount, R. Chandy, D. Carlson, K. Ulrich, L. Carin, D. Dunson, S. Kumar, K. Deisseroth, S. D. Moore, K. Dzirasa*. “Dysregulation of prefrontal cortex-mediated slow evolving limbic dynamics drives stress-induced emotional pathology.” Neuron, 2016 Jul 20;91(2):439-52. doi: 10.1016/j.neuron.2016.05.038